SR proteins are ‘locators’ of the RNA splicing machinery
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چکیده
منابع مشابه
SR proteins are ‘locators’ of the RNA splicing machinery
For those of us used to hearing with our ears, it is difficult to imagine how the fish or amphibian perceives its environment on the basis of information from the lateral line sensory system. The lateral line system detects vibrations in the water, a process that has been termed ‘svenning’ — after Sven Dijkgraaf (1908–1995), a founder figure in lateral line research — and is neatly summarised i...
متن کاملUtilization of host SR protein kinases and RNA-splicing machinery during viral replication.
Although the viral genome is often quite small, it encodes a broad series of proteins. The virus takes advantage of the host-RNA-processing machinery to provide the alternative splicing capability necessary for the expression of this proteomic diversity. Serine-arginine-rich (SR) proteins and the kinases that activate them are central to this alternative splicing machinery. In studies reported ...
متن کاملThe distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2
The mammalian cell nucleus is functionally compartmentalized into various substructures. Nuclear speckles, also known as interchromatin granule clusters, are enriched with SR splicing factors and are implicated in gene expression. Here we report that nuclear speckle formation is developmentally regulated; in certain cases phosphorylated SR proteins are absent from the nucleus and are instead lo...
متن کاملTHE ROLE OF SR AND SR‐RELATED PROTEINS IN pre‐mRNA SPLICING
Pre‐mRNA splicing requires the activities of small nuclear ribonucleoproteins and other essential splicing factors. Among these are members of the SR protein family and SR‐related proteins, which are integrally involved in regulating exon recognition, spliceosomal assembly, and spliceosomal re‐arrangements to promote intron excision. This chapter will focus on the discovery of SR proteins and S...
متن کاملIsolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition.
Serine/arginine (SR) proteins, one of the major families of alternative-splicing regulators in Eukarya, have two types of RNA-recognition motifs (RRMs): a canonical RRM and a pseudo-RRM. Although pseudo-RRMs are crucial for activity of SR proteins, their mode of action was unknown. By solving the structure of the human SRSF1 pseudo-RRM bound to RNA, we discovered a very unusual and sequence-spe...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1999
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(99)80032-3